Download e-book for iPad: Analytical Method Development and Stability Studies of by Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu

By Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu

ISBN-10: 3656948895

ISBN-13: 9783656948896

Master's Thesis from the 12 months 2011 within the topic medication - Pharmacology, grade: 8.0, , path: B.Pharm.,M.Pharm, language: English, summary: A opposite section excessive functionality liquid chromatographic strategy (HPLC) has been constructed for the tactic improvement validation of Carvedilol in bulk and pharmaceutical formula through the use of YMC PACK professional 4.6 X one hundred fifty mm (5µm Particle size). The cellular section used to be Buffer: Acetonitrile: (70:30) and pH used to be adjusted to two pumped at a movement expense of one ml/min and the eluents have been monitored at 320nm. Linearity used to be acquired within the focus diversity of 10-90 μg/ml. The retention time of Carvedilol used to be discovered to be 3.2 minute. the tactic used to be established for specificity, accuracy, precision, linearity, and restrict of detection, restrict of quantification, robustness and solubility balance. LOD and LOQ have been discovered to be 0.001 μg/ml and 0.011μg/ml respectively. the tactic used to be statistically verified and RSD used to be came across to be below 2% indicating excessive measure of accuracy and precision of the proposed HPLC process. balance examine document published that the drug is weak for acidic, alkaline, oxidative, photolytic and UV degradation. The drug is good to thermal degradation. extra over the degradants have been good separated from its API. as a result of its simplicity, rapidness, excessive precision and accuracy, the proposed HPLC technique can be utilized for deciding upon Carvedilol in bulk drug samples or in pharmaceutical dosage forms.

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Analytical Method Development and Stability Studies of Carvedilol by Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu


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